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Abstract #0791

Disentangling the contributions of brain tissue fraction and composition to quantitative MRI

Shir Filo1, Oshrat Shtangel1, and Aviv Mezer1

1The Edmond and Lily Safra Center for Brain Science, The Hebrew University of Jerusalem, Jerusalem, Israel

In-vivo quantitative MRI (qMRI) aims at characterizing the biological properties of brain tissue. However, qMRI parameters are sensitive both to the molecular tissue properties and to the water content within each voxel. We introduce a novel approach that disentangles these two contributions to qMRI parameters and provides tissue-specific measurements. This is achieved by evaluating the dependency of qMRI parameters on the non-water fraction. Using phantoms, we show that this dependency changes as a function of molecular composition. In the human brain, our method reveals unique tissue signatures for different brain regions, along with region-specific age-related changes.

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