Gluteus maximus biomechanical properties and composition are altered in spinal cord injured (SCI) subjects and increase the risk of deep tissue injury type of pressure ulcers. For this purpose, a multi-parametric MRI study of the gluteus maximus of SCI and able-bodied subjects was performed. The protocol consisted of MRE, T2-mapping, and Dixon. The gluteus maximus of SCI subjects had a lower stiffness, which was accompanied by a higher fat fraction, as compared to the able-bodied subjects. The proposed protocol has great potential in providing personalized information on deep tissue injury risk.