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Abstract #0823

MR elastography and multiparametric MRI of chronic pancreatitis reversal after bariatric surgery in obese rats

Philippe Garteiser1, Vinciane Rebours1,2, Sabrina Doblas1, Gwenael Pagé1, André Bado1, Valérie Paradis1,3, Maude Le Gall1, Anne Couvelard1,4, and Bernard E Van Beers1,5

1UMR 1149 Center For Research on Inflammation, Inserm, Paris, France, 2Beaujon Hospital, Pancreatology, AP-HP, Clichy, France, 3Beaujon Hospital, Pathology, AP-HP, Clichy, France, 4Bichat Hospital, Pathology, AP-HP, Paris, France, 5Beaujon Hospital, Radiology, AP-HP, Clichy, France

In obesity, pancreas is affected by fatty infiltration and fibrosis. Bariatric surgery is one of the only therapies which demonstrably improves pancreas status in obesity. In the present work we investigated the mechanical properties at several frequencies, the PDFF and the T2* of pancreatic explants in an obese rat model of bariatric surgery. Bariatric surgery reversed the MRI parameters to values not significantly different than controls. MRI parameters closely matched the reference histology observations. MRE and multiparametric MRI may be used to monitor pancreatic status and treatment response in an obese rat model of bariatric surgery.

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