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Abstract #0831

MRI predicts histopathologic composition of ileal Crohn's disease.

Mathilde Wagner1,2, Mabel Huaibin Ko3, Manjil Chatterji4, Cecilia Besa4, Joana Torres5, Xiaofei Zhang3, Hinaben Panchal5, Judy Cho5, Jean-Frederic Colombel5, Noam Harpaz3, and Bachir Taouli2,4

1Radiology, Pitié Salpêtrière Hospital, UPMC, Paris, France, 2Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, 3Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, 4Radiology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, 5Gastroenterology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States

The aim of our study was to assess the value of MRI for the characterization of histopathologic tissue composition of small bowel Crohn’s disease (CD), including assessment of inflammation, fibrosis and smooth muscle hypertrophy. Our results showed that MRI-based parameters including ADC, MaRIA score and layered pattern of enhancement can predict the degree of bowel inflammation. We also showed that wall thickness measured on T2WI can distinguish prominent muscle hypertrophy from prominent fibrosis in ileal CD.

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