Abstract #0873

Evaluation of task-induced δCMRO2 with a simultaneous acquisition of CBV, CBF and BOLD signals during normoxia and hypoxia conditions

Yaoyu Zhang^1,2, Yayan Yin^1,3, Long Qian¹, Yang Fan⁴, Bing Wu^1,4, and Jia-Ηοng Gao^1,3

¹Center for MRI Research, Peking University, Beijing, China, ²Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China, ³Beijing City Key Lab for Medical Physics and Engineering, Peking University, Beijing, China, ⁴MR Research China, GE Healthcare, Beijing, China

Existing studies have reported various results regarding CMRO₂ behaviors during hypoxia. In this study, a simultaneous acquisition of CBV, CBF and BOLD signals was implemented to evaluate task-induced δCMRO₂ under both normoxia and hypoxia conditions. Of 40 subjects who completed two runs of block-designed, black-and-white checkerboard visual tasks (normoxia and hypoxia) and a CO₂ challenge, we found δCMRO₂ increase significantly during hypoxia. We reckon that the simultaneous acquisition technique makes it possible for all necessary data to be acquired in one run of task, thus minimizing motion and physiological artifacts caused by separate data acquisitions through task repetitions.

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