We performed Monte-Carlo simulations of the diffusion process in 3D biomimetic geometries accounting for the angular dispersion and tortuosity present in white matter. Diffusion MRI data synthesis using clinically plausible trapezoidal OGSE sequences was then performed and an extra-axonal linear-in-frequency dependence of the perpendicular diffusivity transverse to axons was observed over a wide range of axon diameter values. Simulated data was fed into an ActiveAx trapezoidal OGSE model accounting for this frequency-dependence. The estimation of axonal diameter is improved by this correction.
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