Abstract #0962

Grading Brain Tumor Using ADC as a Marker of Cellularity: Fact or Fiction

Zezhong Ye¹, Joshua Lin¹, Richard Price², Jeff Viox¹, Michael Wallendorf³, Sonika Dahiya⁴, Albert H. Kim², and Sheng-Kwei Song¹

¹Radiology, Washington University School of Medicine, St. Louis, MO, United States, ²Neurological Surgery, Washington University School of Medicine, St. Louis, MO, United States, ³Biostatistics, Washington University School of Medicine, St. Louis, MO, United States, ⁴Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States

Here we demonstrate that ADC is not a reliable imaging biomarker of tumor cellularity in high grade glioma since ADC does not consistently correlate with histology determined tumor cellularity. In contrast, diffusion MRI Histology (D-Histo) derived restricted isotropic diffusion fraction demonstrated a significantly positive correlation with histology determined cellularity in high grade glioma.

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