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Abstract #0966

Hyperpolarized 129Xe MR spectroscopy detects short-term changes in lung gas exchange efficiency in idiopathic pulmonary fibrosis

Nicholas David Weatherley1, Neil Stewart1, Graham Norquay1, Ho-Fung Chan1, Oliver Rodgers1, Madhwesha Rao1, Guilhem Collier 1, Helen Marshall1, Matthew Austin1,2, Laurie Smith1,3, Stephen Renshaw1, Stephen Bianchi2, and Jim Wild1

1University of Sheffield, Sheffield, United Kingdom, 2Sheffield Teaching Hospitals, Sheffield, United Kingdom, 3Sheffield Children's Hospital NHS Foundation Trust, Sheffield, United Kingdom

Idiopathic pulmonary fibrosis (IPF), once thought of as an orphan lung disease, is now a frontrunner in respiratory research. However, progress is hampered by a lack of sensitive biomarkers. Hyperpolarized xenon MR spectroscopy has demonstrated sensitivity to gas exchange in IPF and is emerging as a feasible imaging biomarker of disease. Here, we demonstrate that this methodology has high reproducibility in the disease state, correlates with clinical outcomes and demonstrates a decline in gas transfer efficiency in the lung over six months in spite of static pulmonary function test metrics.

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