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Abstract #0967

Hyperpolarized 129Xe Gas Exchange MRI: The Transition from 1.5 to 3 Tesla

Ziyi Wang1, Mu He2, Elianna Bier3, Brian Soher4, Joseph Mammarappallil4, Sudarshan Rajagopal5, Yuh-Chin Huang6, and Bastiaan Driehuys1,3,4

1Biomedical Engineering, Duke University, Durham, NC, United States, 2Electrical and Computer Engineering, Duke University, Durham, NC, United States, 3Medical Physics Graduate Program, Duke University, Durham, NC, United States, 4Radiology, Duke University Medical Center, Durham, NC, United States, 5Division of Cardiology, Duke University Medical Center, Durham, NC, United States, 6Division of Pulmonary, Allergy and Critical Care, Duke University Medical Center, Durham, NC, United States

Hyperpolarized 129Xe is uniquely suited to imaging pulmonary functions by virtue of its solubility and abundant chemical shifts. Previous efforts established single-breath 3D imaging of 129Xe ventilation, barrier uptake and RBC transfer at 1.5 Tesla. As MR vendors are increasingly transitioning their multinuclear platforms to 3 Tesla, it becomes important to enable 129Xe gas exchange MRI at higher field strengths. Here we demonstrate that by careful measurement of spectral properties and optimization of RF and readout, short T2* can be overcome, and 129Xe gas exchange MRI with quantitative workflow is feasible and robust at 3 Tesla.

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