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Abstract #0972

Dependence of the Chemical Shift of 129Xe Dissolved in Red Blood Cells on Transit Time from the Lung Gas Exchange Region in Rats

Yonni Friedlander1,2, Brandon Zanette1,2, Elaine Stirrat1, Marcus Couch1,2, Andrea Kassner1,3, and Giles Santyr1,2

1Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Medical Imaging, University of Toronto, Toronto, ON, Canada

The chemical shift of 129Xe dissolved in red blood cells was measured at increasing transit times from the gas exchange region of the lungs of healthy rats and rats exposed to hyperoxia/hypoxia, a model of bronchopulmonary dysplasia. The results show that the chemical shift decreased with increasing transit times. Furthermore, the chemical shift was different between the healthy and exposed cohorts. A possible mechanism for this phenomenon based on changes in bulk magnetic susceptibility distal to the lungs is proposed.

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