Abstract #0983

Magnetic resonance spectroscopic imaging based biomarkers of Parkinson’s disease with mild cognitive impairment registered to MNI152 brain atlas after chemical shift correction

Sevim Cengiz¹, Dilek Betul Arslan¹, Ani Kicik², Emel Erdogdu³, Muhammed Yildirim¹, Zeynep Tufekcioglu⁴, Basar Bilgic⁴, Hasmet Hanagasi⁴, Aziz Mufit Ulug¹, Hakan Gurvit⁴, Tamer Demiralp^2,5, and Esin Ozturk-Isik¹

¹Biomedical Engineering Institute, Bogazici University, Istanbul, Turkey, ²Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, ³Psychology and Cognition Research Institute, Bremen University, Bremen, Germany, ⁴Department of Neurology, Istanbul University, Istanbul, Turkey, ⁵Department of Physiology, Istanbul University, Istanbul, Turkey

Mild cognitive impairment in Parkinson’s disease (PD-MCI) is one of the most significant risk factors for Parkinson’s disease dementia. In this study, we defined proton magnetic resonance spectroscopic imaging (1H-MRSI) based biomarkers of PD-MCI. After chemical shift misregistration correction and registration to MNI152 brain atlas of multi-voxel 1H-MRSI data, 101 regions defined in MNI structural and Harvard-Oxford cortical and subcortical structural atlases were analyzed for metabolic differences between PD-MCI, cognitively normal PD (PD-CN) and healthy controls. Temporal occipital fusiform cortex, and posterior divisions of parahippocampal gyrus and right temporal fusiform cortex were indicated as the main regions for metabolic differences.

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