Abstract #1001

Higher-Resolution Prostate Diffusion MRI with Minimized Echo Time using Eddy Current Nulled Convex Optimized Diffusion Encoding (ENCODE)

Zhaohuan Zhang^1,2, Kevin Moulin¹, Eric Aliotta¹, Sepideh Shakeri¹, Sohrab A. Mirak¹, Daniel B. Ennis^1,2, and Holden H. Wu^1,2

¹Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States

Higher-resolution prostate DWI has the potential to improve prostate cancer diagnosis, but suffers from additional SNR reduction due to increased TE at longer EPI readouts for current diffusion encoding schemes. In this work, we evaluated the newly proposed Eddy Current Nulled Convex Optimized Diffusion Encoding to achieve eddy-current-free diffusion encoding with minimized TE for prostate diffusion MRI using standard and higher-resolution protocols. The ENCODE higher-resolution protocol achieves higher scores for image sharpness and contrast compared to standard-resolution prostate DWI.

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