Abstract #1015

Dopamine Release and Neural Activation Differs between Control and MDD during Reward Anticipation: a Simultaneous [11C]Raclopride PET-fMRI Study

Xue Zhang^1,2, Fuyixue Wang^3,4, J. Paul Hamilton⁵, Jingyuan E. Chen¹, Ian H. Gotlib⁶, Mehdi Khalighi⁷, and Gary H. Glover¹

¹Radiological Sciences Laboratory, Department of Radiology, Stanford University, Palo Alto, CA, United States, ²Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, ³Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, ⁴A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ⁵Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden, ⁶Department of Psychology, Stanford University, Palo Alto, CA, United States, ⁷Applied Science Lab, GE Healthcare, Menlo Park, CA, United States

The interaction between the midbrain dopaminergic system and the striatum is implicated in reward processing; it is still unknown, however, how this interaction is altered in Major Depressive Disorder (MDD). In the current study, we compared coupling of dopamine release/binding and neural activity in adults diagnosed with MDD and healthy controls (CTLs) during a monetary incentive delay (MID) task using simultaneous $$$[^{11}C]$$$Raclopride PET and fMRI. We obtained significant correlations in CTLs but not in MDD patients, indicating that the decoupling of dopaminergic system and striatum, especially nucleus accumbens, may play a vital role in the pathophysiology of MDD.

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