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Abstract #1054

Myocardial Infarct Border Zone Metabolism Measured by Hyperpolarized 13C-Pyruvate MRI

James J Pilla1, Gabor Mizsei1, Jerry Zsido II1, Norman Butler1, Yoshiaki Saito1, Gabrielle Pilla1, Akito Imai1, Keitaro Okamoto,1, Christopher L Gade2, Mehrdad Pourfathi1, Kai Ruppert1, Stephen L Kadlecek1, Sarmad Siddiqui1, Rahim R Rizi1, Joseph H Gorman III1, Robert C Gorman1, and Terence Gade1

1University of Pennsylvania, Philadelphia, PA, United States, 2Weill Medical Coll of Cornell NY, New York, NY, United States

Adverse remodeling after a myocardial infarct has been linked to the elevated wall stress in the myocardium adjacent to the infarct (i.e. border zone). Perturbed metabolism in this region could drive the transition from compensated to adverse remodeling. To evaluate regional metabolism this study compared the uptake and intracellular conversion of [1-13C]pyruvate using hyperpolarized 13C. An infarct model of ventricular remodeling was used to investigate region metabolism. Pharmacologic stress produced an increase in remote metabolite flux compared to border zone region which may provide a metabolic mechanism for the established association of mechanical stress and adverse cardiac remodeling following infarct.

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