Abstract #1066

Water suppression in the human brain with hypergeometric RF pulses for single- and multi- voxel MR spectroscopy

Kimberly Chan^1,2,3, Ronald Ouwerkerk⁴, and Peter Barker^2,3

¹Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States, ²Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States, ³F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States

In this study, a novel water suppression sequence with hypergeometric RF pulses (HGWS) is investigated and compared to the commonly used VAPOR sequence in simulations, single and multi- voxel acquisitions. In simulations, HGWS and VAPOR are insensitive to B1 and water T1 variations, but with no B1 variation, HGWS has a lower average residual water fraction than that of VAPOR. In vivo, HGWS provides better water suppression than VAPOR in both single-voxel and multi-voxel acquisitions with a shorter sequence duration.

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