Characterization of skull-brain interactions during applied motion is essential to understanding the mechanics of traumatic brain injury. In this study, MR elastography was performed on volunteers to study in vivo skull-brain motion responding to different vibrational directions using a multi-excitation driver. With novel dual-saturation imaging and dual-sensitivity motion encoding schemes, we directly measured relative skull-brain displacement on a voxel basis. Our results show that the skull-brain interface tends to significantly attenuate and delay rotational motion compared to translational motion. In slip interface imaging, the skull-brain slip interface is not completely evident, and the slip pattern is spatially heterogeneous.