Abstract #1074

In Vivo MR Elastography in Abdominal Aortic Aneurysm Porcine Model: A Comparison to Burst Testing and Mechanical Testing

Huiming Dong^1,2, Matthew Joseph³, Alan Litsky², Xiaokui Mo⁴, Prateek Kalra¹, Richard White¹, and Arunark Kolipaka¹

¹Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ²Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, ³Dorothy M. Davis Heart and Lung Research Institute Interventional Cardiology Catheterization Core Lab, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ⁴Center for Biostatistics, The Ohio State University, Columbus, OH, United States

Abdominal aortic aneurysm (AAA) can result in death due to rupture. Aortic stiffness is an important biomechanical property that can potentially provide accurate rupture risk evaluation. MR elastography (MRE) is a non-invasive technique to estimate aortic stiffness and has not been validated. Therefore, the aim of this study is to use in vivo aortic MRE to estimate aortic stiffness in AAA-induced animal models, and compare it with mechanical testing as well as burst testing. Results demonstrated that aortic stiffness was significantly higher in AAA when compared to normal aorta, while bursting pressure and peak stress was significantly lower in AAA.

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