Abstract #1079

Imaging-Based Spirometry in Chronic Obstructive Pulmonary Disease (COPD) Patients using Phase Resolved Functional Lung Imaging (PREFUL)

Andreas Voskrebenzev^1,2, Filip Klimeš^1,2, Marcel Gutberlet^1,2, Till Kaireit^1,2, Christian Schönfeld^1,2, Julius Renne^1,2, Heike Biller^2,3, Jens Hohlfeld^2,3, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hanover, Germany, ³Clinical Airway Research, Fraunhofer Institute of Toxicology and Experimental Medicine, Hanover, Germany

Recently, an alternative proton lung MRI Fourier Decomposition (FD) method for phase resolved functional lung imaging (PREFUL) was proposed. Using a sine model, respiratory and cardiac cycles with increased temporal resolution are obtained, enabling the assessment of dynamic parameters. Similar to flow-volume loops in spirometry, the regional ventilation can be quantified in terms of fractional ventilation (FV) loops. In this study the FV loops of six healthy volunteers and 16 chronic obstructive pulmonary disease patients are evaluated. As a metric the cross-correlation to a healthy reference is used. The results suggest potential benefits for early detection or treatment monitoring.

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