Abstract #1082

A Technique for Quantitatively Measuring Gas Uptake in the Lung and its Distribution to the Kidneys Using Hyperpolarized Xenon-129 MR Imaging

Hooman Hamedani¹, Stephen Kadlecek¹, Kai Ruppert¹, Yi Xin¹, Mehrdad Pourfathi¹, Sarmad Siddiqui¹, Faraz Amzajerdian¹, Luis Loza¹, Harrilla Profka¹, Ryan Baron¹, Tahmina Achekzai¹, Shampa Chatterjee², Maurizio Cereda³, and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Physiology, University of Pennsylvania, Philadelphia, PA, United States, ³Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

Hyperpolarized ¹²⁹Xe was used before to image lung function and structure. It was also shown to be a very good marker of oxygen diffusion and uptake from the lung, and a surrogate for alveolar wall thickness. Here, we demonstrated a technique for quantitatively measuring gas uptake in the lung and its distribution to the kidney and calculate the arrival time of the gas to the kidneys. Appropriate acquisition parameters will enable the same technique to be used to measure the gas’ arrival at the heart, specific vasculature, or other organs/tissue as appropriate to specific disease states.

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