Oxygen-enhanced 3D radial UTE MRI (UTE OE-MRI) has the potential for dynamic imaging of oxygen wash-in and wash-out in the lungs with isotropic resolution and full chest coverage. Four normal subjects underwent DESPOT1 and ~13-min dynamic OE-MRI using 3D radial UTE MRI. Temporal variations in median percent signal enhancement (MPSE) strongly correlated (p<0.0001) in the lungs and aorta. Wash-in (0.61±0.13 min) and wash-out (0.30±0.18 min) time constants for partial pressure of oxygen (ΔPO2) time curves are comparable to values in the literature. This study shows feasibility for dynamic imaging with whole lung coverage and isotropic spatial resolution for clinical research.