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Abstract #1093

Diffusion-time dependence of diffusional kurtosis in the mouse brainĀ using pulsed and oscillating gradients

Manisha Aggarwal1, Kyle Martin2, Matthew Smith2, and Peter Calabresi2

1Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Non-vanishing excess kurtosis and diffusion-time dependence are two key hallmarks of non-Gaussian or restricted water diffusion in complex brain tissue microenvironments. However, the relation between diffusional kurtosis and diffusion time in the brain remains elusive. In this work, we investigated the time-dependence of diffusional kurtosis in the mouse brain using pulsed- and oscillating-gradient (PGSE and OGSE) diffusion kurtosis imaging (DKI). The results of this work reveal unique tissue contrasts based on the time-dependence of diffusional kurtosis in both gray and white matter, with sensitivity to probe region-selective microstructural changes due to cuprizone-induced demyelination.

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