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Abstract #1105

Differences between treated glioblastoma and metastatic brain neoplasms revealed by non-Gaussian diffusion MRI and 18F-FET-PET

Farida Grinberg1,2, Francesco D’Amore1, Ganna Blazhenets1, Ezequiel Farrher1, Karl-Josef Langen1,3,4, and N. Jon Shah1,2,4

1Institute of Neuroscience and Medicine 4, Research Centre Juelich, Juelich, Germany, 2Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 3Center of Integrated Oncology (CIO), Universities of Cologne and Bonn, Cologne, Germany, 4JARA - BRAIN - Translational Medicine, RWTH Aachen University, Aachen, Germany

Metastatic brain tumours constitute the majority of all brain tumours in adult population. Differentiation of metastases from primary brain tumours such as malignant gliomas may be a diagnostic problem and is important because of different treatment strategies. Recently, and advanced diffusion MRI method, diffusion kurtosis imaging, has been shown to provide information on tumour grade of cerebral gliomas. The purpose of this work was to study the potential of two non-Gaussian diffusion methods, including diffusion kurtosis imaging and gamma-distribution-function imaging, in differentiation of the brain metastases and high-grade tumours.

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