Ubiquitous mitochondrial creatine kinase (CKMT1) is an important mitochondrial membrane component responsible for the reversible conversion of creatine (Cr) to phosphocreatine (PCr). This study shows that in five breast cell lines of varying aggressiveness, 1H MRS-detected PCr levels correlated with CKMT1 mRNA expression. CKMT1 expression was significantly downregulated in triple-negative breast cancer cells compared to estrogen receptor (ER)/ progesterone receptor (PR)-positive cells, and nonmalignant cells. CKMT1 is a prognostic indicator in several cancers; thus, PCr holds promise as potential marker for improved cancer diagnosis, patient stratification, and theranostic treatment monitoring.
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