This study introduces an image-based technique for prospective motion correction in multiband fMRI utilizing multislice-to-volume image registration. Motion detection is based on a single multiband excitation and readout, which allows a high temporal resolution and does not depend on the repetition time or the total number of slices. Results show high accuracy in correcting involuntary as well as intentional head movements in typical fMRI experiments. Residual motion parameters were observed to be within the ranges ±0.2mm/±0.2° without and ±0.5mm/±0.5° with intentional head movements. Comparison with volume-to-volume based prospective motion correction demonstrated an improved performance for high-frequency components of motion.