Renal stiffness was investigated using MR elastography (MRE) and tomoelastography data processing in healthy controls and patients with lupus nephritis (LN). Our results showed that patients had lower renal stiffness than controls, while subregions such as medulla and inner cortex allowed to differentiate early chronic kidney disease (CKD=1) from progressed disease stages based on MRE values. The observed reduction in renal stiffness is associated with decreased ADC-values and increased T2*-values due to LN with CKD≥2. The decreased stiffness due to CKD=1 was reflected by T2*-values but not by ADC-values. MRE provided the highest diagnostic accuracy for detection of LN.