Abstract #1240

Longitudinal Evaluation of Glioblastoma (GBM) Response to Chemo-radiation with Quantitative Magnetization Transfer (qMT)

Hatef Mehrabian^1,2, Sten Myrehaug³, Hany Soliman³, Arjun Sahgal³, and Greg J Stanisz¹

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ³Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Assessing response of glioblastoma (GBM) to standard 6-week chemo-radiation at early stages of the treatment allows for changing or adjusting therapy in patients with progressive tumors. Quantitative magnetization transfer (qMT) which probes the properties of the macromolecular content of the tumor and their interactions with free water protons is more sensitive to treatment-induced effects and is capable of differentiating progressors from non-progressors as early as two weeks into the treatment. Moreover, certain qMT parameters (i.e. amount of MT and direct effect of free water pool) were capable of characterizing GBM aggressiveness even before the start of the treatment.

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