Epithelial ovarian cancer and triple negative breast cancer (TNBC) are aggressive cancers with poor survival outcomes. Simultaneous FDG-PET/MRI and quantitative cell tracking were used to monitor orthotopic ovarian cancer and TNBC models for longitudinal tumor growth and metabolism in response to therapy while tracking immune cell subsets labeled with superparamagnetic iron oxide (SPIO). PET/MRI enabled monitoring of tumor growth and internal physiological changes and allowed quantitative assessment of tumor volumes over time. MRI cell tracking results indicated changes in the recruitment rates of three unique immune cell types over time in the group level with significant individual-level variability.
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