Nephron endowment is a strong predictor for renal health and nephron loss is a hallmark of early development of chronic kidney disease, but there are no techniques to measure nephron endowment in vivo. Here, we performed CFE-MRI in rats and mice to determine the limits of in vivo measurements of nephron endowment in vivo. We correlated in vivo measurements with measurements from ex vivo, high-resolution images of same kidneys. This work lays the foundation for consistent and accurate whole kidney glomerular number and size measurements in the mouse and rat kidney, in vivo.
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