Abstract #1268

Tongue deformation during mandibular advancement, as determined using tagged-MRI, may help to predict mandibular advancement treatment outcome in Obstructive sleep apnoea.

Lauriane Jugé^1,2, Fiona Knapman¹, Peter Burke^1,2, Elizabeth Brown^1,3, Jane Butler^1,2, Danny Eckert^1,2, Jo Ngiam⁴, Kate Sutherland^4,5, Peter Cistulli^4,5, and Lynne Bilston^1,6

¹Neuroscience Research Australia, Sydney, Australia, ²School of Medical Sciences, University of New South Wales, Sydney, Australia, ³Prince of Wales Hospital, Sydney, Australia, ⁴Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, Australia, ⁵Charles Perkins Centre, University of Sydney, Sydney, Australia, ⁶Prince of Wales Clinical School, University of New South Wales, Sydney, Australia

Tongue deformation during mandibular advancement, as characterised by tagged-MRI, may be helpful to predict mandibular advancement splint (MAS) therapy for obstructive sleep apnea (OSA). 68 OSA patients untreated underwent a MRI scan prior to trialling a MAS and treatment outcome was determined. Preliminary results identified 3 possible tongue deformations (en bloc, oropharyngeal and minimal/backward) with variable impact on the upper airway size. Over all participants, tongue deformation was not associated with treatment outcome, but among obese participants, “en bloc” tongue deformation was associated with positive treatment outcomes. This may also improve the understanding of the mechanisms underpinning MAS therapy effectiveness.

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