Magnetic resonance spectroscopy (MRS) can be used to investigate metabolite concentration changes correlated to neurological and psychiatric diseases. Improved spectral resolution and metabolite quantification in these disorders would add to our understanding of neurodegenerative diseases. JSASSI is a novel technique for localized two-dimensional (2D) MRS, based in part on the JPRESS spectroscopic sequence while implementing pulses from the SASSI sequence. An incrementing Δt1 time delay is introduced for resolving J-coupled metabolites from overlapping resonances. JSASSI was applied in phantoms and in vivo. Metabolite peaks for NAA, Glx, Cr and others were clearly identified using JSASSI. Unambiguous detection and resolution of J-coupled metabolites could facilitate reliable quantification of metabolites such as GABA, with potential applications in characterization and treatment monitoring in psychiatric disorders.
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