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Abstract #1282

Finger tapping induces lactate increase in the human motor cortex detected by J-edited 1H-MRS at 4T

Yury Koush1, Robin A. de Graaf1, Lihong Jiang1, Douglas L. Rothman1, and Fahmeed Hyder1

1MRRC, Yale University, New Haven, CT, United States

While functional MRI (fMRI) localizes regions of activation, functional MRS (fMRS) provides metabolic response to activation. fMRS, using short echo-time (TE) non-edited 1H-MRS protocols, has been shown to be capable of detecting a lactate increase in sensory-induced activations. Because short TE non-edited lactate spectra are susceptible to functional hyperemia and contamination from lipids/macromolecules, we posited if long TE J-edited 1H-MRS detection of lactate can reliably detect metabolic changes in the motor cortex (MC) during the standard finger-tapping paradigm. Our fMRS results at 4T showed significant physiological modulation of the MC lactate level.

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