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Abstract #1294

Accelerated Correlated Spectroscopic Imaging in Two Spectral-Three Spatial Dimensions with Slice-selective Adiabatic Refocusing Pulses in Human Calf Muscles

Manoj K Sarma1, Andres Saucedo1, Christine H Darwin2, Neil Wilson1, Zohaib Iqbal1, Cathy C Lee2,3, Catherine Carpenter4, Theodore Hahn2,3, and M. Albert Thomas1

1Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 2Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 3Greater Los Angeles Veterans Affairs Medical Center, Los Angeles, CA, United States, 4School of Nursing, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

An optimized version of the five-dimensional (5D) echo-planar correlated spectroscopic sequence using an adiabatic full passage (AFP) RF pulse pair has been implemented on a 3T MRI/MRS scanner equipped with a 15-channel transmit/receive coil. The sequence was initially tested using a corn oil phantom. The calf muscle of twelve healthy subjects (age 27.5±3.1 years) and six diabetic type 2 subjects was studied (age 62.3±9.8 years). The AFP pulse pair enabled a sharper profile and minimal chemical shift misregistration. The localization of the volume of interest showed differential distribution of metabolites and lipids in human calf muscle and tibial marrow.

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