This work presents a new method for quantifying multiple-TE/two-dimensional spectroscopy data, characterized by the use of spectral priors obtained by quantum mechanical simulations and an experimentally measured lineshape distortion function derived from a set of multi-TE water spectroscopic data. Results from in vivo J-resolved spectroscopy data demonstrated the excellent fitting produced by the proposed method, and improved robustness over a standard parametric-model-based method. With further developments, such as extensions to different sequences and Cramer-Rao bound analysis, the proposed method should prove useful for a range of 2D spectroscopy experiments.
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