Abstract #1338

Gene Expression Profiling to Understand the 1H MRS Characterization of the VEGF Metabolic Secretome from a Triple Negative Human Breast Cancer Xenograft

Santosh Kumar Bharti¹, Balaji Kirshnamachary¹, Louis Dore-Savard², Brett Stark¹, Aleksander S. Popel³, and Zaver M Bhujwalla^1,4

¹Division of Cancer Imaging Research, Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, ²McGill University Health Centre and RI-MUHC, Montreal, QC, Canada, ³Systems Biology Laboratory, Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore, MD, United States, ⁴Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, MD, United States

Vascular endothelial growth factor (VEGF A) is a potent regulator of angiogenesis, invasion, and metastasis, especially in breast cancer. Secreted VEGF that forms a part of the interstitial milieu along with other metabolites shapes the microenvironment. Here, using 1H MR spectroscopy and microarray, we have characterized the metabolic and gene signature of the tumor tissue derived from MDA-MB-231 cells that stably overexpressed VEGF gene. Metabolic changes supported by gene array data provide new insight into the role played by VEGF in breast cancer progression

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