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Abstract #1354

A 1H/31P MRS study of ATP and GABA modulation induced by anodal transcranial direct current stimulation in primary motor cortex of healthy subjects

Harshal Jayeshkumar Patel1, Chang-Hoon Choi2, N. Jon Shah2,3, and Ferdinand Binkofski1,2

1Division of Clinical Cognitive Sciences, Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany, 2Institute of Neuroscience and Medicine - 4, Forschungszentrum J├╝lich GmbH, 52425, Juelich, Germany, 3Faculty of Medicine, Department of Neurology, RWTH Aachen University, JARA, Aachen, Germany

Transcranial direct current stimulation (tDCS) modulates cerebral energy and cortical inhibition. In this study we investigated long-term effects of anodal stimulation on inhibitory neurotransmitter and energy phosphate concentration using proton and phosphorous magnetic resonance spectroscopy. Our results indicate immediate GABA reduction following anodal tDCS and further maintaining the decreased state until the end of the experiment. ATP/Pi and PCr/Pi show initial reduction following anodal tDCS and further sign of recovery by the end of the experiment.

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