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Abstract #1367

Does maternal swimming during gestation protects the neonatal brain from hypoxic-ischemic injury?

Yohan van de Looij1,2,3, Eduardo Sanchez1, Petra S Hüppi1, and Stéphane V Sizonenko1

1Service développement et croissance, Université de Genève, Geneva, Switzerland, 2Laboratoire d'imagerie fonctionnelle et métabolique, Ecole polytechnique fédérale de Lausanne, Lausanne, Switzerland, 3Institut translationnel d'imagerie moléculaire, Université de Genève, Geneva, Switzerland

There are growing evidences that swimming during gestation has a neuroprotective effect on offspring perinatal brain injuries. The aim of this work was to assess this neuroprotective effect on P3 hypoxic-ischemic model by 1H-MRS and diffusion MRI (DTI and NODDI) at 9.4T. A moderate, but real effect of swimming during gestation on the neurochemical profile 24h after HI was observed. Difference in neurochemical profile between sedentary and swimming rats may lead to a different response to the injury. At long-term, diffusion MRI derived parameters changes following HI were restored in the swimming HI group, providing evidence of a neuroprotective effect.

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