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Abstract #1373

Associations between Osteoarthritis Molecular Biomarkers and MR-based cartilage composition and Knee Joint Morphology: Data from the Osteoarthritis Initiative

Gabby B Joseph1, Michael C Nevitt2, Charles E McCulloch2, Jan Neumann1, John A Lynch2, Ursula Heilmeier1, Nancy E Lane3, and Thomas M Link1

1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, United States, 3Department of Rheumatology, University of California, Davis, Davis, CA, United States

This study assessed the relationships of serum/urine biomarkers for osteoarthritis with MR imaging measures of joint structure and composition, using data from the Osteoarthritis Initiative (OAI). Significant positive correlations between the serum/urine biomarkers (sHA, sMMP3) and MRI cartilage T2 relaxation time measurements, compositional markers of early cartilage degeneration were observed. However, no significant associations were found with cartilage morphology or Kellgren-Lawrence (KL) grade. Therefore, serum biomarkers and cartilage T2 composition may reflect similar features of the pathophysiology of cartilage matrix degenerative disease.

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