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Abstract #1375

Magnetization Transfer Ratio (MTRNOE) as a Biomarker of Hip Osteoarthritis

Hatef Mehrabian1, Jasmine Rossi-Devries1, Alan L Zhang2, Richard B Souza3, and Sharmila Majumdar1

1Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, United States, 3Physical Therapy, University of California, San Francisco, San Francisco, CA, United States

Loss of cartilage collagen, proteoglycans (PG), glycosaminoglycans (GAG) are responsible for osteoarthritis (OA). MRI biomarkers T2 (sensitive to collagen), magnetization transfer (MT) and T, (sensitive to PG), and GAGCEST (sensitive to GAG) can detect OA at early stages. Similar to GAGCEST, CEST signal of Nuclear Overhauser Effect (NOECEST) at -1.6ppm also changes with OA. However, unlike GAGCEST, this NOECEST is measurable at 3T which is suitable for hip. MT ratio at this -1.6ppm (MTRNOE) represents the combination of MT, T2, NOECEST effects. OA-related changes in these three parameters result in decreased MTRNOE making it a reliable biomarker for OA.

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