The ischemia-reperfusion paradigm can be used to evaluate skeletal muscle and peripheral vascular function. To induce ischemia, a cuff is inflated to a suprasystolic pressure, which leads to occlusion of the blood vessels, and reactive hyperemia results upon cuff deflation. This study was done to determine whether the rate at which the cuff inflates affects the hyperemic response. MRI data were acquired using the ischemia-reperfusion paradigm under slow and fast cuff inflation rates with PIVOT and projection velocity mapping in eight healthy subjects. The results suggest that there were no significant differences between hyperemic responses from slow and fast inflations.