Five healthy volunteers were scanned at 3 T to determine the time to contrast equilibrium in skeletal leg muscle to establish whether extracellular volume (ECV) mapping is clinically feasible for skeletal muscle (as it has proved to be for myocardium). Time to contrast equilibrium was 13 minutes, and native T1 values were validated against the literature. It was also found that the difference in measurement of ECV using the aorta compared to the femoral artery was small. It is hoped that advancements in this technique could aid in the diagnosis and treatment of scleroderma patients with muscle involvement.
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