Muscular dystrophy is a family of inherited diseases characterized by progressive muscle weakness that leads to muscle damage and wasting. Clinical measures of muscular dystrophy rely on surgical biopsy, which is invasive and limited. Magnetic resonance imaging (MRI) can provide valuable information pertaining to tissue characteristics of this disease noninvasively. We performed multi-parametric MRI to assess the changes due to muscle damage and subsequent recovery over 3 weeks starting at 12 weeks of age in disease affected mice. The differences observed through MRI measurements demonstrate MRI can be used effectively to track disease progression and responses to future therapy.