Abstract #1494

Hybrid Proton Resonance Frequency Shift and Variable Flip Angle T1 Temperature Mapping using a Golden-Angle 3D Stack-of-Radial Technique

Le Zhang¹, Tess Armstrong^1,2, Samantha Mikaiel^1,2, Alan Priester³, Rory Geoghegan⁴, Shyam Natarajan^3,4, and Holden Wu^1,2,4

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine, University of California Los Angeles, Los Angeles, CA, United States, ³Urology, University of California Los Angeles, Los Angeles, CA, United States, ⁴Bioengineering, University of California Los Angeles, Los Angeles, CA, United States

Proton resonance frequency shift (PRF) is widely used for MR temperature mapping, but is not applicable in adipose tissues. T₁ measurement is an alternative MR temperature mapping method that can be applied in adipose tissues. Combined PRF-T₁ mapping has been evaluated for Cartesian MRI, but there is a lack of research for non-Cartesian techniques. In this work, we propose a new multi-echo 3D stack-of-radial technique that combines PRF and variable-flip-angle T₁ measurement for MR temperature mapping. Preliminary results from laser ablation in phantoms demonstrate good agreement between temperature derived from both PRF and T₁ compared to readings of temperature probes.

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