In this work, a hybrid ARFI sequence based on segmented SE-EPI is proposed to simultaneously monitor the displacement and T2 change of tissue during HIFU therapy. The reliability of this sequence was validated first. The quantified displacement and T2 show good consistence with the reference ARFI and SE results. The hybrid sequence was then applied before and after HIFU therapy to evaluate the treatment effects. With the occurrence of ablative lesion, T2 relaxation time decreased in the lesion center and increased in the boundary. While the displaced region (region with obvious displacement) and the maximal displacement at focus both enlarged. In general, this hybrid ARFI is a potentially useful HIFU monitoring method in clinical application.