A multiparametric MR approach using total choline (tCho), apparent diffusion coefficient (ADC) and tumor volume was undertaken for prediction of pathological response in 42 locally advanced breast cancer (LABC) patients undergoing neoadjuvant chemotherapy (NACT). 24 were pathologically responders (complete and partial) while 18 were non-responders. Percentage change in tCho, ADC and volume was higher in pathological responders than in non-responders after III NACT. Individually, all three parameters showed equal sensitivity (66.7%) with specificity in the range 64.7% to 70.6% for pathological response prediction. Combination of all three MR parameters yielded 66.7% sensitivity and a specificity of 64.7%.