In this feasibility study, we have characterized the mechanical properties of lymphoma directly in the cervical lymph nodes with in vivo multifrequency MRE for the first time. Both MRE and diffusion weighted imaging were used to investigate the tumor's response to chemotherapy. We found that lymphomas stiffened 24 hours after chemotherapy which was accompanied by increased apparent diffusion coefficient (ADC) and reduced tumor volume. Wave speed obtained from MRE is sensitive in detecting the mechanical response of lymphoma to chemotherapy. Observed tumor stiffening post treatment needs to be validated by larger group size and should be explained by histological analysis.