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Abstract #1578

Spatial normalization of individual fractional anisotropy (FA) maps to widely used population templates for analysis can increase variability and create spurious differences in the measured FA values

Amritha Nayak1,2, Elisabeth Wilde3, Brian Taylor3, CENC Neuroimaging Core Investigators4, Laura Reyes1,2, and Carlo Pierpaoli1

1Quantitative Medical Imaging Section, NIBIB, NIH, Bethesda, MD, United States, 2The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc, Bethesda, MD, United States, 3Michael E.DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX, United States, 4Chronic Effects of Neurotrauma Consortium, Richmond, VA, United States

In this study we evaluate the effects of spatial normalization of individual fractional anisotropy (FA) maps to widely used population templates for analysis and its introduction of variability, creating spurious differences in the measured FA values.

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