Multi-compartment modelling of Diffusion-Weighted MRI data can provide additional diffusion related parameters. However, to ensure meaningful parameters are attained, multi-compartment models have to make several assumptions prior to fitting, including initial parameter values and multi-step fitting procedures. The novel Autoregressive Discrete Acquisition Points Transformation (ADAPT) method was applied to in vivo data. ADAPT demonstrated that it could infer the number of compartments within the data. When 1- and 2-compartment ADAPT models were investigated, the ADAPT coefficients were found to correlate with the parameters attained by the Apparent Diffusion Coefficient (ADC) and the Intravoxel Incoherent Motion (IVIM) models.