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Abstract #1657

Diffusion tensor MR imaging of optic radiation in advanced bilateral glaucoma patients in comparison to normal control subjects

Chanon Ngamsombat1, Thanakorn Chareankarunyuta1, Prapaporn Pornwuthi1, Panida Charnchaowanish1, Yudthaphon Vichianin2, Ngamkae Ruangvaravate3, Shuo Zhang4, and Orasa Chawalparit1

1Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, 2Department of Radiological Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand, 3Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, 4Philips Healthcare, Singapore, Singapore

Glaucoma is a worldwide leading cause of irreversible vision loss characterized by degeneration of retinal ganglion cells. The damage can be found in visual pathway beyond retina and optic disc to visual cortex. Diffusion tensor MR imaging (DTI) is widely used for evaluation of early microstructural change in the brain parenchyma. Here we reported abnormal change of the optic radiation in advanced bilateral glaucoma patients using DTI as compared to the age-matched normal control subjects. The obtained DTI parameters may serve as potential quantitative imaging biomarkers to provide complementary indication of the disease condition in glaucoma.

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