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Abstract #1670

DW-MRI in assessment of 3D Cell Culture

Jui-Heng Lin1, Hao-Chun Peng1, Shao-Chieh Lin2, Yi-Jui Liu2, Ruey-Hwang Chou3, Ke-Sin Yan3, Tan-Wei Liao3, Chia-Wei Lin4, Chao-Chun Lin4, Wei-Ching Lin 4, and Wu-Chung Shen4

1Master's Program of Biomedical Informatics and Biomedical Engineering, Feng Chia University, Taichung, Taiwan, 2Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, 3Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan, 4Department of Radiology, China Medical University Hospital, Taichung, Taiwan

In extracellular and intracellular space, the Brownian motion of water is restricted by organelles, cellmembranes, and extracellular fibers. DWI is sensitivity to microscopic motion, which is due to Brownian motion of water molecules. In this study, 3D cell culture with hydrogels ECM was used to investigate whether DWI may provide information on these microenvironmental parameters and the microenvironment-associated metastatic propensity of tumors. Our results demonstrated DW-MRI may provide the potential biomarkers on the change of microenvironment in the application of 3D cell culture experiment.

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Abstract