To estimate the physical features of intra-voxel axon bundles in the detection of axon damage it is important to compute bundle-wise apparent diffusivities. There is a first family of methods that factors-out the effects of the orientation-dispersion under a convolution model (e.g. Spherical Mean), and a second family that associates the diffusivity properties with specific orientations (e.g. Gaussian-Mixture-Models). Here we demonstrate that only the second family provides bundle-wise apparent diffusivities, and thus it provides the useful information for clinical applications. This is demonstrated on a broad synthetic validation as well as on ad-hoc rat ex-vivo phantom with a damaged bundle.
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